Cancer is entangled with metabolic alterations.

Despite altered metabolism was one of the first hallmarks of cancer identified, only recent technical development allowed us to analyze the complexity of the metabolic networks in tumors. Growth, survival, and stromal crosstalk are only few of the processes that requires alterations in the cell metabolism.  Indeed, metabolic fluxes are also governing a plethora of other processes, such as cell signaling and epigenetic pathways.

Cancers are characterized by a high metabolic heterogeneity to foster cancer cell survival and proliferation in extreme microenvironmental conditions, including hypoxia, depletion of metabolic resources, and acidosis. Therefore, this uniquely harsh microenvironment represents a valuable target for diagnosis and therapy, which still needs to reach its full potential.

The principal aim of this congress is to present the most recent advances on cancer metabolism, with a special focus on the interactions between stromal and cancer cells and on the alterations of the various hallmarks of cancer